{"name":"Loadbay","description":"Catalog of harnesses for AI agents, across domains.","repo":"https://github.com/alessandrorodi/loadbay","count":34,"domains":{"trading":"Trading","coding":"Coding & DevOps","browser":"Browser & computer","productivity":"Productivity","data":"Data & search","social":"Social & comms","health":"Health","science":"Research & science","gaming":"Gaming","media":"Voice & media","robotics":"Robotics"},"traits":{"mcp":"Exposes an MCP server","keys":"Needs API keys / auth","sandbox":"Runs sandboxed","guard":"Guardrails / limits"},"harnesses":[{"slug":"denario","name":"Denario","author":"AstroPilot-AI","domain":"science","integrations":["Research"],"language":"Python","license":"GPL-3.0","stars":573,"traits":["oss","keys"],"summary":"A modular multi-agent system that assists with scientific research end to end.","repo":"https://github.com/AstroPilot-AI/Denario","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/denario","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"bioagents","name":"BioAgents","author":"bio-xyz","domain":"science","integrations":["Biology"],"language":"TypeScript","license":"Unlicensed","stars":171,"traits":["oss","keys"],"summary":"An AI-scientist framework for autonomous deep research in the biological sciences.","repo":"https://github.com/bio-xyz/BioAgents","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/bioagents","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"paper-qa","name":"paper-qa","author":"Future-House","domain":"science","integrations":["arXiv","Semantic Scholar"],"language":"Python","license":"Apache-2.0","stars":8722,"traits":["oss","keys"],"summary":"High-accuracy RAG framework for answering questions from scientific papers with grounded citations.","repo":"https://github.com/Future-House/paper-qa","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/paper-qa","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"chemcrow","name":"chemcrow-public","author":"ur-whitelab","domain":"science","integrations":["RDKit"],"language":"Python","license":"MIT","stars":927,"traits":["oss","keys"],"summary":"LLM chemistry agent that augments models with expert tools for synthesis planning and molecule discovery.","repo":"https://github.com/ur-whitelab/chemcrow-public","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/chemcrow","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"zotero-mcp","name":"zotero-mcp","author":"54yyyu","domain":"science","integrations":["Zotero"],"language":"Python","license":"MIT","stars":3868,"traits":["mcp","oss"],"summary":"MCP server linking a Zotero research library to AI assistants for paper search, summaries, and citation analysis.","repo":"https://github.com/54yyyu/zotero-mcp","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/zotero-mcp","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"semantic-scholar-mcp","name":"semantic-scholar-mcp","author":"akapet00","domain":"science","integrations":["Semantic Scholar"],"language":"Python","license":"MIT","stars":24,"traits":["mcp","oss"],"summary":"MCP server for searching and analyzing academic papers and citation graphs via the Semantic Scholar API.","repo":"https://github.com/akapet00/semantic-scholar-mcp","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/semantic-scholar-mcp","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"genomas","name":"GenoMAS","author":"Liu-Hy","domain":"science","integrations":["GEO","TCGA"],"language":"Python","license":"MIT","stars":136,"traits":["oss","keys"],"summary":"Multi-agent framework that automates gene-expression analysis workflows end to end.","repo":"https://github.com/Liu-Hy/GenoMAS","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/genomas","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"cassia","name":"CASSIA","author":"ElliotXie","domain":"science","integrations":["scRNA-seq"],"language":"Python","license":"MIT","stars":96,"traits":["oss","keys"],"summary":"Multi-agent LLM framework for automated cell-type annotation of single-cell RNA-seq data.","repo":"https://github.com/ElliotXie/CASSIA","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/cassia","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"proteinmcp","name":"ProteinMCP","author":"charlesxu90","domain":"science","integrations":["RFdiffusion","ESMFold"],"language":"Python","license":"MIT","stars":56,"traits":["mcp","oss"],"summary":"Agentic framework for autonomous protein design wrapping structure-prediction and sequence-design tools.","repo":"https://github.com/charlesxu90/ProteinMCP","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/proteinmcp","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"alphafold-mcp-server","name":"AlphaFold-MCP-Server","author":"Augmented-Nature","domain":"science","integrations":["AlphaFold"],"language":"JavaScript","license":"Other","stars":35,"traits":["mcp","oss"],"summary":"MCP server exposing the AlphaFold Protein Structure Database for structure-prediction analysis through agent tools.","repo":"https://github.com/Augmented-Nature/AlphaFold-MCP-Server","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/alphafold-mcp-server","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"cactus-chem","name":"cactus","author":"pnnl","domain":"science","integrations":["RDKit"],"language":"Python","license":"BSD-3-Clause","stars":52,"traits":["oss"],"summary":"LLM agent that leverages cheminformatics tools to answer chemistry questions with informed tool use.","repo":"https://github.com/pnnl/cactus","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/cactus-chem","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"atlas-bo","name":"atlas","author":"aspuru-guzik-group","domain":"science","integrations":["Olympus"],"language":"Python","license":"MIT","stars":51,"traits":["oss"],"summary":"Bayesian optimization brain for self-driving laboratories that plans experiments for autonomous discovery.","repo":"https://github.com/aspuru-guzik-group/atlas","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/atlas-bo","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"matagent","name":"MatAgent","author":"adibgpt","domain":"science","integrations":["Materials Project"],"language":"Python","license":"MIT","stars":22,"traits":["oss","keys"],"summary":"Physics-aware multi-agent LLM framework for accelerating materials-science discovery and optimization.","repo":"https://github.com/adibgpt/MatAgent","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/matagent","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"buildarena","name":"BuildArena","author":"AI4Science-WestlakeU","domain":"science","integrations":["Besiege"],"language":"Python","license":"Other","stars":94,"traits":["oss"],"summary":"Benchmark where LLM agents design, build, and test rockets, cars, and bridges in a physics simulator from text goals.","repo":"https://github.com/AI4Science-WestlakeU/BuildArena","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/buildarena","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"arxiv-mcp-server","name":"arxiv-mcp-server","author":"blazickjp","domain":"science","integrations":["arXiv"],"language":"Python","license":"Apache-2.0","stars":2900,"traits":["mcp","oss"],"summary":"An MCP server for searching and analyzing arXiv papers, so a research agent can pull and read the literature.","repo":"https://github.com/blazickjp/arxiv-mcp-server","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/arxiv-mcp-server","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"ai-scientist","name":"AI-Scientist","author":"SakanaAI","domain":"science","integrations":["OpenAI","Anthropic","Semantic Scholar","LaTeX"],"language":"Python","license":"Apache-2.0","stars":14000,"traits":["oss","keys","sandbox"],"summary":"First end-to-end system for fully automated open-ended scientific discovery: generates ideas, runs experiments, and writes papers.","repo":"https://github.com/SakanaAI/AI-Scientist","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/ai-scientist","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"ai-scientist-v2","name":"AI-Scientist-v2","author":"SakanaAI","domain":"science","integrations":["OpenAI","Anthropic","Semantic Scholar","LaTeX"],"language":"Python","license":"Apache-2.0","stars":6600,"traits":["oss","keys","sandbox"],"summary":"Agentic successor that uses progressive tree search to autonomously generate hypotheses, run ML experiments, and write manuscripts.","repo":"https://github.com/SakanaAI/AI-Scientist-v2","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/ai-scientist-v2","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"paper-search-mcp","name":"paper-search-mcp","author":"openags","domain":"science","integrations":["arXiv","PubMed","Semantic Scholar","OpenAlex"],"language":"Python","license":"MIT","stars":1900,"traits":["oss","mcp","keys"],"summary":"MCP server to search and download academic papers across 20+ sources including arXiv, PubMed, bioRxiv, and Semantic Scholar.","repo":"https://github.com/openags/paper-search-mcp","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/paper-search-mcp","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"biomni","name":"Biomni","author":"snap-stanford","domain":"science","integrations":["Anthropic","OpenAI","MCP"],"language":"Python","license":"Apache-2.0","stars":3200,"traits":["oss","mcp","keys"],"summary":"General biomedical AI agent that combines LLM reasoning, retrieval-augmented planning, and code execution over a biomedical toolbox.","repo":"https://github.com/snap-stanford/Biomni","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/biomni","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"storm","name":"STORM","author":"stanford-oval","domain":"science","integrations":["OpenAI","Bing","You.com"],"language":"Python","license":"MIT","stars":14000,"traits":["oss","keys"],"summary":"Stanford knowledge-curation system that researches a topic via internet search and writes a full-length, cited report.","repo":"https://github.com/stanford-oval/storm","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/storm","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"boltz","name":"Boltz","author":"jwohlwend","domain":"science","integrations":["PyTorch","MSA servers"],"language":"Python","license":"MIT","stars":4100,"traits":["oss","keys"],"summary":"Open family of biomolecular interaction models for predicting protein and complex structures and binding affinity, an AlphaFold3-class tool.","repo":"https://github.com/jwohlwend/boltz","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/boltz","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"alphafold3","name":"AlphaFold 3","author":"google-deepmind","domain":"science","integrations":["JAX","PDB"],"language":"Python","license":"Other","stars":8200,"traits":["oss","keys"],"summary":"Official DeepMind inference pipeline for AlphaFold 3, predicting joint structures of proteins, nucleic acids, ligands, and ions.","repo":"https://github.com/google-deepmind/alphafold3","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/alphafold3","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"esm","name":"ESM3","author":"evolutionaryscale","domain":"science","integrations":["PyTorch","HuggingFace"],"language":"Python","license":"Other","stars":2200,"traits":["oss","keys"],"summary":"EvolutionaryScale flagship protein language models (ESM3, ESM C) reasoning jointly over sequence, structure, and function.","repo":"https://github.com/evolutionaryscale/esm","community":false,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/esm","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"gpt-researcher","name":"gpt-researcher","author":"assafelovic","domain":"science","integrations":["OpenAI","Anthropic","Tavily Search","Google Search","LangChain"],"language":null,"license":"Apache-2.0","stars":28053,"traits":["oss","keys"],"summary":"Autonomous deep-research agent that plans and executes multi-step web research on any topic, synthesizing comprehensive reports from multiple LLMs and sources that other agents can act on.","repo":"https://github.com/assafelovic/gpt-researcher","community":true,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/gpt-researcher","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"deeptutor","name":"DeepTutor","author":"HKUDS","domain":"science","integrations":["Claude Code","OpenAI Codex","OpenAI","Anthropic","local LLMs"],"language":null,"license":"Apache-2.0","stars":28764,"traits":["oss","keys"],"summary":"Agent-native learning workspace explicitly designed to be operated by other AI agents, connecting tutoring, research, quiz generation, visualization, and mastery practice with JSON output modes for agent integration.","repo":"https://github.com/HKUDS/DeepTutor","community":true,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/deeptutor","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"scientific-agent-skills","name":"scientific-agent-skills","author":"K-Dense-AI","domain":"science","integrations":["RDKit","Scanpy","PyTorch Lightning","PubMed","ChEMBL","UniProt","PubChem"],"language":null,"license":"MIT","stars":33496,"traits":["oss","keys"],"summary":"A library of 161 pre-built agent skills covering biology, chemistry, genomics, drug discovery, and clinical research, compatible with Claude Code, Cursor, and Codex. Agents install skills via npx to gain access to 100+ scientific databases and specialized research analysis workflows.","repo":"https://github.com/K-Dense-AI/scientific-agent-skills","community":true,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/scientific-agent-skills","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"agentic-pymol","name":"agentic-pymol","author":"Arcadia-Science","domain":"science","integrations":["PyMOL 2.6+","Claude Code","Codex","MCP-compatible clients"],"language":null,"license":"MIT","stars":89,"traits":["oss","mcp"],"summary":"A lightweight MCP server that exposes PyMOL as a typed tool surface for AI agents, enabling programmatic control of molecular visualization sessions. Returns structured data (coordinates, distances, RMSDs, sequences) rather than plain text for downstream agent reasoning.","repo":"https://github.com/Arcadia-Science/agentic-pymol","community":true,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/agentic-pymol","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"openresearch-cli","name":"openresearch-cli","author":"alphaXiv","domain":"science","integrations":["Claude Code","Codex","OpenCode","Slurm","Kubernetes","Ray","Hugging Face Jobs","Modal"],"language":null,"license":"MIT","stars":533,"traits":["oss","keys","sandbox"],"summary":"CLI framework that runs parallel AI research agents to review literature, develop hypotheses, run experiments, and produce research artifacts. Multiple agents explore independent directions in isolated git worktrees using Claude Code, Codex, or OpenCode as the underlying model.","repo":"https://github.com/alphaXiv/openresearch-cli","community":true,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/openresearch-cli","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}},{"slug":"wisp-science","name":"wisp-science","author":"xuzhougeng","domain":"science","integrations":["MCP","Python","R","Scientific databases","Claude"],"language":null,"license":"AGPL-3.0","stars":1097,"traits":["oss","mcp","sandbox"],"summary":"Open-source, local-first desktop AI research workbench for scientific computing with built-in MCP. 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Built on OASIS/CAMEL-style social simulation for decision rehearsal.","repo":"https://github.com/666ghj/MiroFish","community":true,"tip":{"method":"x402","network":"eip155:8453","endpoint":"/api/tip/mirofish","note":"GET with an x402 client to tip the author; returns 402 with payment requirements until paid."}}]}